Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
نویسندگان
چکیده
A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
منابع مشابه
Haliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa
In the aim of searching for new antifungal products from marine origin, we have isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa using bio-guided (antifungal) HPLC methods. The molecular structure of this compound was elucidated by spectrometric techniques IR, UV, MS and NMR. The isolated metabolite show...
متن کاملChemical control of epibiosis by Hong Kong sponges: the effect of sponge extracts on micro- and macrofouling communities
The relationship between antifouling metabolite production and epibiosis on the surfaces of the sponges Haliclona cymaeformis, Haliclona sp. and Callyspongia sp. was investigated in this study. Densities of macrofoulers and diatoms were suppressed on the surfaces of all examined sponges, while densities of bacteria on the surfaces of H. cymaeformis and Callyspongia sp. were similar to those on ...
متن کاملIdentification species of Demospongiae sponge at Assaluyeh Persian Gulf
The marine environment is a rich source of biodiversity and chemical compounds, and based on biodiversity knowledge, it is believed that the highest biodiversity is related to living organisms in tropical and semi-equatorial regions. The goal of this study was the biodiversity of Demospongiae sponge in Assaluyeh area in May 2018. Sampling carried oyu by using Coadrat in three sites with three r...
متن کاملAntibacterial activity of actinomycetes isolated from native sponge of Persian Gulf (Kharku Island) against pathogens
Resistant of pathogens to common antibiotics is a major global problem, and efforts discover new antibiotics from less known resources, is an inevitable. Native sponges of Persian Gulf have high potential in the field of medical biology, but have received little attention. In this study, actinomycetes that capable to produce anti-bacterial metabolites isolated and examined. Two sponges of Persi...
متن کاملDraft Genome Sequence of the Antimycin-Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans
Streptomyces sp. strain SM8, isolated from Haliclona simulans, possesses antifungal and antibacterial activities and inhibits the calcineurin pathway in yeast. The draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. Several secondary metabolite biosynthetic gene clusters are present, encoding known and novel metabolites, including antimycin.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Marine Drugs
دوره 5 شماره
صفحات -
تاریخ انتشار 2007