Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand

نویسندگان

  • Rawiwan Wattanadilok
  • Pichan Sawangwong
  • Cátia Rodrigues
  • Honorina Cidade
  • Madalena Pinto
  • Eugenia Pinto
  • Artur Silva
  • Anake Kijjoa
چکیده

A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.

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عنوان ژورنال:
  • Marine Drugs

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2007